Dr Jayant Patel will be in Australia on Monday, with US marshals expected to hand him over to the custody of two Queensland detectives in Los Angeles on Sunday night.
The detectives will escort Dr Patel on to a Qantas flight that departs LA at 11.20pm local time (1620 AEST Sunday). The flight will land in Brisbane about 6am Monday (AEST).
Dr Patel is being held at LA's Metropolitan Detention Centre and he will be taken by US marshals to LA airport.
The two Queensland detectives, Darryl Johnson and Graham Walker, will take custody of Dr Patel at the airport.
It is believed they will not handcuff him for the 14-hour flight.
Dr Patel, 58, is facing 13 charges, including manslaughter, stemming from his time as director of surgery at the Bundaberg Base Hospital from 2003 to 2005.
A US District Court judge placed a July 21 deadline on the process, with Dr Patel to be released on strict bail conditions if he was not extradited by that time.
Meanwhile, former patients of the surgeon are scrambling to get from Bundaberg to Brisbane.
Bundaberg Hospital Patients Support Group spokeswoman Beryl Crosby said the news was a great relief to her, but she was now in a panic trying to organise transport to Brisbane to be in the courtroom.
"Obviously instant relief, and probably panic now how I'm getting to Brisbane," she told AAP.
"I was actually booked on (Monday) night's train out of Bundaberg, and there's no night train (Sunday night) so we're trying to figure out a way of getting there."
Two other members of the group will also make the trip with Ms Crosby, likely to be by road.
The trio expect to commute between the two cities regularly over the coming months.
"I've done that a lot in the past, I sat through the whole commission of inquiry, and I've done it many times since," Ms Crosby said.