More than $1 million worth of drugs has been seized by police and 13 people arrested during raids in Sydney's southwest.
It's believed the two syndicates were responsible for around 10,000 amphetamine and ecstasy deals every fortnight on the streets of Campbelltown.
After a five month investigation police raided 11 homes overnight at Ingleburn, Blair Athol and Campbelltown - seizing drugs worth a million dollars, 22 firearms, two stolen cars and other property.
Thirteen people have been arrested, charged with more than 60 serious drug and firearms offences.
Police said an escalation in violent assaults in licensed premises led them to investigate the source of the drugs on the streets.
"There was more to the puzzle than just alcohol and we began to see a pattern where an apparent combination of hard liquor and drugs seemed to be triggering the violence," Detective Superintendent Stuart Smith said.
"Working backwards from the assaults my officers were able to unravel and identify two complex drug networks operating in the Campbelltown area working separately but between them supplying a variety of drugs.
"Now, not only have we allegedly uncovered those supplying the deals on the streets but also those further up the chain sourcing and manufacturing the drugs."